Alzheimer Dementia

The patient was a 74 year old woman who was healthy and took no medications She developed difficulty with recalling recent events, names, and appointments. The family reported slow, gradual progression over 2 years. She was able to care for her ailing husband, and required only occaisional assistance from family members in keeping track of financial affairs. MR images show a mild degree of cerebral atrophy, as slight widening of the hemispheric sulci, prominent in the parietal and perisylvian regions. Perfusion SPECT is abnormal in a pattern consistent Alzheimer's disease: temporo- parietal reductions in blood flow, as compared, for example, with frontal regions.
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Keith A. Johnson (, J. Alex Becker (