RSDS often follows trauma or surgery. In 506 patients selected by Sleinert from a large post-operative series, 25% followed operations for crush injuries, 25% followed elective operations in the upper extremities., e.g., carpal tunnel release, palmar fasciotomies, and 50% followed sprains, contusions and other operations. Symptoms begin immediately after injury in 30% of patients; in the remainder they usually start during the first week.
The Should Hand Syndrome is a variant of RSDS often related to myocardial infarction, cervical disk herniation and degenerative disease of the cervical spine.
Other correlates of RSDS include sepsis, systemic viral infections and spinal cord concussion. RSDS may occur in many hospitalized stroke patients. Kozin reports a figure of 14% and Tepperman 25%. Rarely RSDS may be associated with underlying carcinoma (bladder, lung and esophagus), herpes zoster and isoniazid therapy.
Local sympathetic blockade is used in therapy and diagnosis.
There has been a great deal of controversy about the precise findings on scintigraphy. Although in adults increased activity is usually observed in the affected regions, Matter studied 32 patients and concluded that the pattern of decreased activity described in children is occasionally encountered in adults. This variability may be related to the interval between onset of symptoms and imaging. Demangeat (3) studied 181 patients with RSDS of the hand providing quantitative measurements of blood flow (DB), blood pool (BP) and delayed images (DI). He divided the studies into three stages based on interval from onset of symptoms.
Stage Weeks BF BP DI 1 0-20 INC INC INC 2 20-60 N INC INC 3 60-100 DEC N N INC=increased, DEC=decreased, N=normalThe reduced flow in advanced RSDS may be due in part to amyotrophia caused by disuse.
Intenzo (7) recently found that 28% of 32 patients with RSDS of the lower extremities had normal scans, 59% showed increased and 13% showed decreased activity; overall sensitivity was 72%. Values for the sensitivity and specificity of the one scan for RSDS vary amongst authors, however. Werner (6) reported a sensitivity of 50% and a specificity of 92% based on the delayed image. When BF and BP images were considered these values were not altered. MacKinnon and Holder (4) reported significantly higher values: sensitivity=96%; specificity=98%.
Goldsmith (5) evaluated the three phase bone scan in children and the lower extremity was affected much more frequently than in adults (12/15). Only one radiograph showed mild diffuse osteopenia, but the bone scan showed decreased uptake in 12/15. Increased uptake was the pattern in two patients. BF and BP images did not increase the sensitivity.
Scintigraphy appears to be a useful guide to prognosis. 90% of patients with positive scintigrams experienced a favorable response to steroids as opposed to 34% of those with negative scintigrams (2).
2) Kozin F, et al. RSDS. AJM 1976; 60:321 and 1981; 70:23-30.
3) Demangeant JL, et al. Three-phase bone scanning in RSDS of the hand. JNM 1988; 29:26-31.
4) MacKinnon SE, Holder LE. The use of three-phase bone scanning in the diagnosis of RSDS. J Hand Surg 1984; 9A:556-563.
5) Goldsmith DP, et al. Nuclear imaging and clinical features of childhood RSDS: comparison with adults. Arthr Rheum 1989; 32:480.
6) Werner R, et al. Factors affecting the sensitivity and specificity of the three-phase bone scan in the diagnosis of RSDS in the upper extremity.
7) Intenzo C, et al. Scintigraphic patterns of RSDS of the lower extremities. Clin Nucl Med 1989; 14(9):657-661.
J. Anthony Parker, MD PhD, email@example.com