Pick's Disease

This 59 year old woman had a three year history of a progressive alteration in social behavior which included apathy and occasional disinhibition. Images reveal severe focal shrinkage of temporal and frontal lobes bilaterally. This can be quickly appreciated using the "cine" button to download an MPEG movie of the entire transaxial stack.
Some details have been altered to protect confidentiality.
Keith A. Johnson (keith@bwh.harvard.edu), J. Alex Becker (jabecker@mit.edu)