Motor Neuron Disease and Alzheimer's Disease

The patient was a 71 year old man who developed muscle wasting and weakness and had electromyographic evidence of motor neuron disease. Approximately one year later he was noted to undergo a profound change in personality, and to develop social inappropriateness, and uncharacteristic use of foul or crude language. At postmortem, brain changes typical of Alzheimer's disease were found.
Some details have been altered to protect confidentiality.
Keith A. Johnson (, J. Alex Becker (